Introduction to traditional Chinese medicine spray drying production experience
Spray drying can directly dry the solution, emulsion, and suspension into a powdery or granular product. The sprayed material or liquid is sprayed into a mist by an atomizer to be dispersed in a hot air stream.
The surface of the droplet is saturated with water. The humidity of the droplet is approximately equal to the temperature of the wet bulb of hot air. Generally, it can be controlled at about 50 °C, so the quality of the dried product is good, especially suitable for heat sensitive materials.
The preparation of the Chinese patent medicine is mostly a compound and the composition is complicated. Therefore, the extract is a mixture of a true solution, a colloid, a suspension and an emulsion. After the Chinese herbal extract is properly concentrated, it is carried out.
Spray drying can form loose powdered or finely divided articles.
Chinese herbal extract, concentrated to a relative density of 1.10 (80 ° C measured) extract, the water content is usually about 83%, if wet granulation, usually more than 10 times the excipients can be granulated
Forming, causing the dosage of proprietary Chinese medicine to be too large; if the extract is spray-dried, a dry extract is usually obtained (water content is about 5% to 7%, and if the water content is less than 4%, the powder may be burnt)
It is brown; if the water content is higher than 12%, the dry extract is bound into a mass, which is difficult to be pulverized and granulated. The yield is about 25%, usually according to the dose ratio: the powder: the auxiliary material is 1:1. Good granulation, effective
The dosage of proprietary Chinese medicines has been reduced, so the spray drying technology of traditional Chinese medicines is very popular among Chinese patent medicine manufacturers. Such as spray drying granulation, silicone glue blood particles (8g · pack-1) and silicone glue
The blood granules (20g·package-1) contain the same amount of traditional Chinese medicine extract.
In the long-term spray drying practice, the author has obtained the following experience: the production workshop must control: 1 the density of Chinese medicine concentrate
If the density of traditional Chinese medicine concentrate is too low, the spray drying speed will be slow and the yield will be low, which will not achieve the purpose of saving time and labor. If the density is too high, the viscosity of the concentrate is too strong, and the spray is dry.
The wall is stuck during the drying process and the spray drying is not achieved. Therefore, when the Chinese medicine concentrate is spray dried, it is necessary to find a suitable density. In general, the density of traditional Chinese medicine concentrate is
When it is about 1.10 (1.05-1.15) (measured at 80 °C), it can be spray-dried well. The different densities of the Chinese medicines are different, and the suitable density of the concentrated liquid for spray drying will be different. Every breed wants
Find the optimum concentrate density.
2 Chinese medicine concentrate temperature
The concentrated Chinese herbal medicine is spray-dried at room temperature (25 ° C). After the steady state is reached, if the temperature of the concentrated liquid is increased, the spray drying and atomization speed will be accelerated, and the concentrate needs to be increased.
The flow rate is maintained in a spray-dry stable state. Therefore, the higher the temperature of the concentrate, the faster the spray drying rate and the higher the yield within the allowable range of production.
3 viscosity of traditional Chinese medicine concentrate
In the traditional Chinese medicine spray drying experiment, the author found that different kinds of traditional Chinese medicine concentrates use GLP-5 pneumatic high-speed centrifugal spray drying when their relative density and temperature are the same.
Spray drying is easy, some difficulties, and some even do not get dry products. The reason is that the viscosity of the concentrate is different, and the variety with high sugar content is easy to cause sticking.
Consequences, especially when the variety contains medicinal materials such as raw land, rehmannia, Ophiopogon japonicus, jujube, medlar, and scutellaria, the concentrate is spray-dried, and the product sticks to the wall and does not reach dryness.
effect. The author concentrated the Zhigancaotang of the medical sage Zhang Zhongjing to a relative density of 1.10 (80 ° C), spray drying, not only the atomization speed is slow, but also the product sticks to the wall. Correct
For traditional Chinese medicine concentrates, centrifugates, and alcohol-liquid sediments that are prone to stick wall phenomenon, an appropriate amount of β-cyclodextrin, soluble starch, white dextrin, etc. may be added to form a suspension, or a temperature rise may be employed.
Ways to reduce viscosity and eliminate sticking. Add 10% white dextrin to the centrifugation solution of Zhigancao Decoction, add 5% β-cyclodextrin to the alcohol solution of cold and antipyretic particles, and use GLP-5 gas.
The high-speed centrifugal spray dryer was spray-dried to obtain a fine granular product. For concentrated liquids with a particularly high viscosity, such as the author encountered the four herbs of rehmannia, medlar, angelica and motherwort
The concentrate of the material is dried by adding 10% soluble starch and raising the temperature above 80 °C to eliminate the sticking phenomenon.
4 Effect of concentrate, centrate, alcohol solution on spray drying
Chinese medicine concentrate, because it contains impurities such as sediment and starch, some products use gravity to remove impurities, the yield is about 99%; but because of the centrifugal force, it is far more than gravity
The sedimentation effect is large, so the centrifugal separation efficiency is high and the purification degree is also high. The high-speed centrifuge has a yield of about 90%; some products use 70% ethanol to remove sediment, starch and protein.
Impurities such as impurities, the yield is about 70%. The same Chinese medicine variety, at the same density, temperature, the concentrate is most easy to spray dry, followed by centrifugation, 70% alcohol liquid is the most difficult to spray dry,
Easy to stick to the wall. This is because their viscosity is small to large. I have used GLP-5 pneumatic high-speed centrifugal spray dryer to carry out 5 batches of ancient Han health tablets.
The juice spray drying test, the results are as follows:
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Concentrate alcohol solution, centrifugation, centrifugation, centrifugation, centrifugation III
Add soluble starch (%) sticky wall
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Non-sticky, non-sticky, non-sticky
Product shape particle sticking into agglomerated pellets
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