On September 3, 2013, the internationally renowned academic journal "Cell Research" published the online research group Zhang Lei and Zhao Yun of the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences entitled "A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity â€. In this work, Guo Tong and others discovered that a new member of the Hippo signaling pathway, SdBP / Tgi, inhibits tissue growth by negatively regulating the activity of the Yorkie-Scalloped complex downstream of the Hippo signaling pathway.
Cell proliferation and apoptosis play a vital role in the homeostasis of the organism. The Hippo signaling pathway controls the size of organs and tissues by regulating cell growth, proliferation and apoptosis. Many of its members have been found to be closely related to the occurrence of human cancer. In Drosophila, the upstream signal of Hippo signal undergoes a series of phosphorylation cascades of kinase complexes, which will eventually phosphorylate the downstream effector Yorkie. Phosphorylated Yorkie is trapped in the cytoplasm and cannot activate the transcription factor Scalloped in the nucleus, thereby regulating the size and volume of the organ.
Under the guidance of researchers Zhang Lei and Zhao Yun, doctoral student Guo Tong and others discovered through a series of genetic, molecular and cell biology methods that the protein SdBP encoded by the fruit fly gene CG10741 directly communicates with Scalloped and Tcallop domains through its TDU and PPXY domains. The transcription factor Yorkie is combined. Through further research, the authors further found that SdBP can directly compete for the combination of Yorkie and Scalloped through the TDU domain, inhibit the activation of Scalloped, and thereby regulate the growth of tissues. Since the Hippo pathway is one of the most conservative signaling pathways in evolution, research on the mechanism of Hippo signal transduction in Drosophila is very important for understanding the mechanism of action of the Hippo signaling pathway in mammals and the targeted treatment of related cancers caused by defects. Important reference significance.
Guo Tong and Lu Yi are the co-first authors of this article. This research was supported and helped by researchers Ji Hongbin and Zhou Zhaocai of the Institute of Biochemistry and Cell Sciences, Chinese Academy of Sciences, and obtained the Ministry of Science and Technology, the National Fund Committee and the Chinese Academy of Sciences ) Funding.
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