Recently, the microfluidic chip research group (group 1807) led by researcher Qin Jianhua of Dalian Institute of Chemical Physics, Chinese Academy of Sciences has made new progress in micro-nanofluidic cytology research. Related results were published in the recently published Advanced Materials magazine.
Biocompatible nanofibers have the functions of simulating extracellular matrix and can realize three-dimensional cell culture and other important functions. The study combined microfluidic technology with nanofiber materials to prepare a fiber structure with a controllable patterning function in a unique way. It successfully achieved the three-dimensional culture of arrayed cells under micro-space conditions, and further studied the interstitial charge. Mesenchymal stem cells grow and differentiate in the microenvironment and other biological behaviors, and also evaluate the sensitivity of liver cancer cells to chemotherapy drugs.
The important significance of this work is that the micro-nano integration method creates a cell microenvironment that is closer to physiological conditions, which is conducive to the study of the interaction between different cells and their growth microenvironment. It is a research on stem cell growth regulation and cell-level high-throughput drugs Screening provides a potentially important platform, as well as a new way of thinking in the fields of regenerative medicine, tissue engineering, and integrated biology.
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