Anti-β2 glycoprotein I antibody autoantigen

Antiphospholipid antibodies are a group of immunoglobulins that can directly react with negatively charged phospholipids and are present in the serum of patients with antiphospholipid syndrome (APS), including anticardiolipin antibodies, anti-β2-glycoprotein I antibodies, antiphosphatidylserine Antibodies and lupus anticoagulants are also common in systemic lupus erythematosus and related connective tissue diseases. Harris et al. Believe that anti-phospholipid antibodies are also related to the tendency to embolism. Schultze et al. Reported for the first time in 1961 that β2-glycoprotein (β2-GPl) had a molecular weight of 50 kD. It was not until the 1990s that it realized that β2-GPI was a plasma protein necessary for the binding of antiphospholipid antibodies to antigens. In 1994, Mastaura discovered that when β2-GPI binds to a negatively charged phospholipid on a lipid membrane, or when β2-GPI is adsorbed on a polystyrene titration plate, a structural epitope recognized by the anti-β2-GPI antibody is formed.

1. Definition β2-GPI is an autoantigen of anti-β2-GPI antibody, an anionic phospholipid protein in the blood circulation, also known as apolipoprotein H. Others believe that anti-β2-GPI antibodies recognize conformational epitopes on β2-GPI. This epitope can be induced only when β2-GPI binds to a phosphatide, cardiolipin-coated titration plate, or a high-binding anion surface.
2. Characteristics β2-GPI is a single-chain polypeptide, containing 326 amino acid residues, consisting of 5 homologous fragments, each fragment is about 60 amino acids, contains highly conserved cystine, proline and tryptophan, the fifth The carboxy terminus of the region has been modified to contain 82 amino acids and 6 cysteine; these repeats are called short repeats or complement regulatory protein repeats. β2-GPI is a synergistic factor of anti-phospholipid antibodies in serum combined with anionic phospholipids, the concentration is about 200gg / ml. β2-GPI can bind a variety of negatively charged substances, such as phospholipids, lipoproteins, etc., inhibit endogenous coagulation pathways, prothrombin activity and ADP-dependent platelet aggregation.
3. Purification: The purified β2-GPI can be isolated by continuous perchloric acid extraction or cardiolipin affinity chromatography and ion exchange chromatography. Using the baculovirus and insect cell SF9 cell lines as expression systems, it can produce a large number of processed and biologically active human kernel 2-GPI recombinant proteins.


  • 10 PIECES Manicure Set : Contains nail and toenail tools for hands,foot and face care.Daily use for men & women
  • High Quality Stainless Steel Tools : Our manicure and pedicure tools are made of professional surgical grade stainless steel to allow safe sterilization, prevent corrosion and minimize risk of Infections.
  • PORTABLE & LIGHTWEIGHT : This manicure set comes with a portable zipper leather case.It is also very lightweight so you can carry it with you in your bag everyday or pack it with you when you go traveling.
  • Perfect Gift : The Set comes in high-grade designed black leather case .It is simple,fashionable & business.Perfect as a gift for men and women.
  • beauty manicure set



Beauty Manicure Set

Beauty Manicure Set,Ladies Manicure Set,Beauty Travel Manicure Set,Baby Grooming Tools

Bonet Houseware Co., Ltd. , https://www.manicureset.de