Mass spectrometry tutorial

1.1 Development history
1. In 1886, E. Goldstein observed positively charged particles in a low-pressure discharge experiment.
2. In 1898, W. Wen discovered that the positively charged particle beam was deflected in the magnetic field.
3. The father of modern mass spectrometry: JJ Thomson (won the Nobel Prize in Physics in 1906).
4. In 1922, FWAston [British] won the Nobel Prize in Chemistry for inventing mass spectrometers. In 1942, the first commercial mass spectrometer.
5. Since the 1950s, research on organic mass spectrometry (organic ion fragmentation mechanism, using mass spectrometry to infer organic molecular structure)
6. Various ion source mass spectrometry, online technology research and its application in the research of biological macromolecules (CI, FD, FAB, ESI-MS, etc.)
1.2 Features:
1. High sensitivity (a few micrograms or less samples, the detection limit can reach 10-14 grams)
2. The only way to determine the molecular formula.
3. Fast analysis speed (a few seconds)
4. Can be used in combination with chromatography.

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